Cajun Chicken Pasta Bake

Featured in: Southern Comfort

This dish combines tender chicken pieces seasoned with smoky Cajun spices, sautéed with colorful bell peppers and red onion, then simmered in a creamy blend of milk and cream with melted mozzarella, cheddar, and Parmesan cheeses. Tossed with pasta and baked until bubbly and golden, it offers a rich, spicy, and satisfying meal perfect for sharing. Garnished with fresh parsley for a bright finish.

Updated on Sat, 15 Nov 2025 14:54:00 GMT
Golden-topped Cajun Chicken Pasta Bake: imagine bubbly cheese over tender chicken and pasta flavors. Save
Golden-topped Cajun Chicken Pasta Bake: imagine bubbly cheese over tender chicken and pasta flavors. | dashofstates.com

A vibrant, comforting casserole featuring tender chicken, spicy Cajun seasonings, creamy sauce, and melty cheese, all baked with pasta for a crowd-pleasing meal.

The first time I baked this Cajun chicken pasta dish, my kitchen filled with the mouthwatering aroma of peppers, spices, and bubbling cheese. It&s now a favorite for when we crave something hearty yet vibrant, and the leftovers are even better the next day.

Ingredients

  • Chicken breasts: 2 large, cut into bite-sized pieces
  • Red bell pepper: 1, diced
  • Yellow bell pepper: 1, diced
  • Red onion: 1 small, diced
  • Garlic: 2 cloves, minced
  • Penne or rigatoni pasta: 300 g (10 oz)
  • Olive oil: 2 tbsp
  • Butter: 1 tbsp
  • Heavy cream: 200 ml (¾ cup)
  • Milk: 120 ml (½ cup)
  • Mozzarella cheese: 100 g (1 cup), shredded
  • Parmesan cheese: 50 g (½ cup), grated
  • Cheddar cheese: 100 g (1 cup), shredded
  • Cajun seasoning: 1½ tbsp, plus extra for garnish
  • Smoked paprika: ½ tsp
  • Salt: ½ tsp
  • Black pepper: ¼ tsp
  • Chili flakes: ¼ tsp, optional, for extra heat
  • Fresh parsley: 2 tbsp, chopped (for garnish)

Instructions

Preheat Oven:
Preheat your oven to 200°C (400°F).
Cook Pasta:
Cook the pasta in salted boiling water 2 minutes less than package instructions. Drain and set aside.
Sauté Chicken:
In a large skillet, heat olive oil and butter over medium-high heat. Add chicken, 1 tbsp Cajun seasoning, salt, and pepper. Sauté until browned and cooked through, about 6 8 minutes. Remove chicken and set aside.
Sauté Vegetables:
In the same skillet, add onions and bell peppers. Cook for 4 5 minutes until softened. Add garlic, smoked paprika, and chili flakes (if using), and sauté for 1 minute.
Make Sauce:
Reduce heat to medium. Pour in cream and milk, stirring to scrape up any browned bits. Simmer for 2 3 minutes.
Add Cheeses:
Add 3/4 of the mozzarella, cheddar, and Parmesan to the sauce. Stir until melted and smooth.
Combine Pasta & Chicken:
Return the chicken to the skillet, then add the cooked pasta. Toss everything together to coat well. Adjust seasoning with extra Cajun spice, salt, or pepper if needed.
Bake:
Transfer mixture to a lightly greased baking dish. Sprinkle remaining cheeses over the top. Bake for 18 20 minutes, until cheese is golden and bubbly.
Garnish & Serve:
Garnish with chopped parsley and a pinch of Cajun seasoning before serving.
A hearty, cheesy Cajun Chicken Pasta Bake with a rich creamy sauce and vibrant bell peppers. Save
A hearty, cheesy Cajun Chicken Pasta Bake with a rich creamy sauce and vibrant bell peppers. | dashofstates.com

This pasta bake has become our go-to on chilly evenings, and my kids love helping sprinkle the cheese before it goes into the oven. Sharing it at the table, surrounded by laughter, makes the meal extra special every time.

Serving Suggestions

Serve this casserole alongside a crisp green salad or some garlic bread for a complete meal. Leftovers reheat beautifully for quick lunches or dinners the next day.

Ingredient Swaps & Add-Ins

Add sliced mushrooms, spinach, or even sundried tomatoes for extra flavor and nutrition. If you prefer a lighter version, try substituting half-and-half for heavy cream, or use rotisserie chicken to save time.

Allergen & Nutrition Info

This dish contains milk and wheat. Always check labels if you or your guests have dietary restrictions. Each serving has approximately 670 calories, 32g fat, 56g carbohydrates, and 40g protein.

Delicious Cajun Chicken Pasta Bake with a touch of heat, featuring a comforting creamy sauce. Save
Delicious Cajun Chicken Pasta Bake with a touch of heat, featuring a comforting creamy sauce. | dashofstates.com

This Cajun chicken pasta bake is packed with flavor and is sure to become a weeknight classic. Enjoy its gooey, spicy comfort with every bite.

Recipe FAQ

What type of pasta works best for this dish?

Penne or rigatoni are ideal as they hold the creamy sauce well and bake evenly with the chicken and cheese.

Can the spice level be adjusted?

Yes, adjust the Cajun seasoning and optional chili flakes according to your preferred heat intensity.

Is it possible to use a lighter dairy option?

Half-and-half can replace heavy cream for a lighter, but still creamy, texture without sacrificing flavor.

How do the vegetables enhance the dish?

Red and yellow bell peppers along with red onion add sweetness and crunch, balancing the spicy Cajun flavors.

What is the best way to reheat leftovers?

Reheat gently in the oven or microwave to maintain the creamy sauce's texture and keep the cheese melty.

Can this be prepared ahead of time?

Yes, assemble the casserole and refrigerate, then bake just before serving for convenience and fresh taste.

Cajun Chicken Pasta Bake

Comforting casserole featuring spicy chicken, creamy sauce, cheese, and pasta baked to golden perfection.

Prep duration
20 min
Cook duration
35 min
Complete duration
55 min
Created by Jordan Miller


Complexity Medium

Heritage American (Cajun-inspired)

Output 4 Portions

Nutritional considerations None specified

Components

Meats

01 2 large chicken breasts, diced

Vegetables

01 1 red bell pepper, diced
02 1 yellow bell pepper, diced
03 1 small red onion, diced
04 2 cloves garlic, minced

Pasta

01 10 oz penne or rigatoni pasta

Sauces & Dairy

01 2 tablespoons olive oil
02 1 tablespoon butter
03 ¾ cup heavy cream
04 ½ cup milk
05 1 cup shredded mozzarella cheese
06 ½ cup grated Parmesan cheese
07 1 cup shredded cheddar cheese

Spices & Seasonings

01 1½ tablespoons Cajun seasoning, plus extra for garnish
02 ½ teaspoon smoked paprika
03 ½ teaspoon salt
04 ¼ teaspoon black pepper
05 ¼ teaspoon chili flakes (optional)

Garnish

01 2 tablespoons chopped fresh parsley

Method

Phase 01

Preheat Oven: Set the oven to 400°F.

Phase 02

Cook Pasta: Boil pasta in salted water for 2 minutes less than package instructions, then drain and set aside.

Phase 03

Sauté Chicken: Heat olive oil and butter in a large skillet over medium-high heat. Add chicken, 1 tablespoon Cajun seasoning, salt, and pepper. Cook for 6 to 8 minutes until browned and cooked through. Remove chicken from skillet.

Phase 04

Cook Vegetables: In the same skillet, cook onion and bell peppers for 4 to 5 minutes until softened. Add garlic, smoked paprika, and chili flakes if using; sauté for 1 minute.

Phase 05

Prepare Sauce: Reduce heat to medium. Stir in heavy cream and milk, scraping browned bits from the bottom. Simmer for 2 to 3 minutes.

Phase 06

Melt Cheese: Add three-quarters of mozzarella, cheddar, and Parmesan cheeses to the sauce. Stir until melted and smooth.

Phase 07

Combine Ingredients: Return chicken to the skillet. Add cooked pasta and toss to coat evenly. Adjust seasoning with additional Cajun seasoning, salt, or pepper as needed.

Phase 08

Assemble Bake: Transfer mixture to a greased 2-quart baking dish. Sprinkle remaining cheeses on top.

Phase 09

Bake: Bake for 18 to 20 minutes until cheese is golden and bubbly.

Phase 10

Garnish and Serve: Sprinkle with chopped parsley and a pinch of Cajun seasoning before serving.

Necessary tools

  • Large skillet or sauté pan
  • Medium saucepan for pasta
  • 2-quart baking dish
  • Wooden spoon
  • Chef's knife and cutting board

Allergy details

Review each component for potential allergens and seek professional medical guidance if you're uncertain.
  • Contains milk (cheese, cream, butter) and wheat (pasta); may contain gluten cross-contamination from spices.

Nutrient breakdown (each portion)

These figures are approximate and shouldn't replace professional health advice.
  • Energy: 670
  • Fats: 32 g
  • Carbohydrates: 56 g
  • Proteins: 40 g