Cajun Chicken Alfredo Fettuccine

Featured in: Southern Comfort

This dish features tender chicken breasts rubbed in bold Cajun seasoning, pan-seared to juicy perfection. A creamy sauce combines Velveeta cheese, butter, garlic, and cream, flavored with Parmesan and a hint of cayenne for subtle heat. Tossed with al dente fettuccine and garnished with fresh parsley, it offers a comforting Southern-inspired twist perfect for any easy weeknight dinner.

Updated on Sun, 23 Nov 2025 12:06:00 GMT
Tender Cajun Chicken Alfredo Fettuccine pasta swimming in a rich, creamy Velveeta sauce, ready to serve. Save
Tender Cajun Chicken Alfredo Fettuccine pasta swimming in a rich, creamy Velveeta sauce, ready to serve. | dashofstates.com

A creamy, spicy pasta dish featuring tender Cajun-seasoned chicken, rich Velveeta cheese sauce, and perfectly cooked fettuccine—comfort food with a Southern twist.

This dish quickly became a favorite at my dinner table for its rich taste and comforting texture.

Ingredients

  • Chicken: 2 large boneless skinless chicken breasts 1 ½ tablespoons Cajun seasoning 1 tablespoon olive oil
  • Pasta: 12 oz (340 g) fettuccine pasta
  • Sauce: 2 tablespoons unsalted butter 2 cloves garlic minced 1 cup (240 ml) heavy cream 8 oz (225 g) Velveeta cheese cubed ½ cup (50 g) grated Parmesan cheese ½ teaspoon black pepper ¼ teaspoon cayenne pepper (optional for extra heat) Salt to taste
  • Garnish: 2 tablespoons fresh parsley chopped Extra grated Parmesan cheese (optional)

Instructions

Step 1:
Bring a large pot of salted water to a boil. Cook the fettuccine according to package instructions until al dente. Drain and set aside reserving ½ cup pasta water.
Step 2:
While the pasta cooks pat chicken breasts dry. Rub both sides with Cajun seasoning.
Step 3:
In a large skillet heat olive oil over medium-high heat. Add chicken and cook 5–6 minutes per side or until golden and cooked through (internal temperature 165°F/74°C). Remove chicken let rest 5 minutes then slice thinly.
Step 4:
In the same skillet reduce heat to medium. Add butter and garlic sauté 1 minute until fragrant.
Step 5:
Stir in heavy cream and bring to a gentle simmer. Add Velveeta cubes stirring often until melted and smooth.
Step 6:
Add Parmesan cheese black pepper and cayenne pepper (if using). Stir until fully combined and creamy. If sauce is too thick add reserved pasta water a little at a time.
Step 7:
Toss cooked fettuccine in the sauce until well coated.
Step 8:
Divide pasta among plates. Top with sliced Cajun chicken. Garnish with parsley and extra Parmesan if desired.
A close-up shot of the savory Cajun Chicken Alfredo Fettuccine, garnished with fresh parsley and Parmesan. Save
A close-up shot of the savory Cajun Chicken Alfredo Fettuccine, garnished with fresh parsley and Parmesan. | dashofstates.com

This meal brings the whole family together especially on busy weeknights when a comforting dish is needed.

Notes

Adjust Cajun seasoning for more or less heat Substitute rotisserie chicken for a quicker version Add sautéed bell peppers or mushrooms for extra flavor and color Pairs well with a crisp green salad and a chilled Chardonnay

Required Tools

Large pot Large skillet Knife and cutting board Tongs or pasta fork Measuring cups and spoons

Allergen Information

Contains milk/dairy (Velveeta Parmesan cream butter) Contains wheat (fettuccine) Contains chicken Those with allergies should check ingredient labels for hidden allergens

Hearty and flavorful: a warm bowl of Cajun Chicken Alfredo Fettuccine with perfectly-cooked chicken, waiting to be enjoyed. Save
Hearty and flavorful: a warm bowl of Cajun Chicken Alfredo Fettuccine with perfectly-cooked chicken, waiting to be enjoyed. | dashofstates.com

This creamy Cajun chicken Alfredo pasta is sure to become a staple for your family dinners.

Recipe FAQ

How do I ensure the chicken stays juicy?

Dry the chicken before seasoning and cook it over medium-high heat until golden, then let it rest 5 minutes before slicing to retain moisture.

Can I adjust the spiciness level?

Yes, modify the amount of Cajun seasoning and cayenne pepper according to your preferred heat intensity.

What pasta is best for this dish?

Fettuccine works well as its flat ribbons hold the creamy Velveeta sauce beautifully.

How to prevent the sauce from being too thick?

Add reserved pasta water gradually to thin the sauce while stirring until desired consistency is reached.

Can I add vegetables?

Sautéed bell peppers or mushrooms enhance flavor and texture, adding color and nutrition.

Cajun Chicken Alfredo Fettuccine

Tender chicken with Cajun spices, fettuccine pasta, and rich Velveeta cheese sauce make a cozy meal.

Prep duration
15 min
Cook duration
25 min
Complete duration
40 min
Created by Jordan Miller


Complexity Easy

Heritage American (Cajun-inspired)

Output 4 Portions

Nutritional considerations None specified

Components

Chicken

01 2 large boneless, skinless chicken breasts
02 1 ½ tablespoons Cajun seasoning
03 1 tablespoon olive oil

Pasta

01 12 oz fettuccine pasta

Sauce

01 2 tablespoons unsalted butter
02 2 cloves garlic, minced
03 1 cup heavy cream
04 8 oz Velveeta cheese, cubed
05 ½ cup grated Parmesan cheese
06 ½ teaspoon black pepper
07 ¼ teaspoon cayenne pepper (optional)
08 Salt to taste

Garnish

01 2 tablespoons fresh parsley, chopped
02 Extra grated Parmesan cheese (optional)

Method

Phase 01

Cook Pasta: Bring a large pot of salted water to a boil. Cook fettuccine according to package instructions until al dente. Drain and reserve ½ cup pasta water.

Phase 02

Prepare Chicken: Pat chicken breasts dry and rub evenly with Cajun seasoning on both sides.

Phase 03

Cook Chicken: Heat olive oil in a large skillet over medium-high heat. Cook chicken 5 to 6 minutes per side until golden and internal temperature reaches 165°F (74°C). Remove and rest for 5 minutes, then slice thinly.

Phase 04

Sauté Garlic: Reduce skillet heat to medium. Add butter and minced garlic, sautéing until fragrant, about 1 minute.

Phase 05

Prepare Sauce: Stir in heavy cream and simmer gently. Add Velveeta cheese cubes, stirring frequently until smooth and melted.

Phase 06

Season Sauce: Incorporate grated Parmesan, black pepper, and cayenne if using. Stir until sauce is creamy; add reserved pasta water gradually if too thick.

Phase 07

Combine Pasta and Sauce: Toss cooked fettuccine in the sauce until fully coated.

Phase 08

Plate and Garnish: Divide pasta onto plates, top with sliced Cajun chicken, and garnish with chopped parsley and extra Parmesan if desired.

Necessary tools

  • Large pot
  • Large skillet
  • Knife and cutting board
  • Tongs or pasta fork
  • Measuring cups and spoons

Allergy details

Review each component for potential allergens and seek professional medical guidance if you're uncertain.
  • Contains milk/dairy products (Velveeta, Parmesan, cream, butter).
  • Contains wheat (fettuccine pasta).
  • Contains poultry (chicken).
  • Check ingredient labels for potential hidden allergens.

Nutrient breakdown (each portion)

These figures are approximate and shouldn't replace professional health advice.
  • Energy: 670
  • Fats: 32 g
  • Carbohydrates: 57 g
  • Proteins: 41 g