High-Protein Pizza Pasta Bake

Featured in: All-American Desserts

This satisfying bake brings together everyone's favorite pizza flavors in a pasta casserole format. Lean ground beef and sliced pepperoni create a protein-rich base, while Greek yogurt and mozzarella form a creamy, bubbly topping. The entire dish bakes up golden and bubbly in about 25 minutes, making it perfect for weeknight dinners or meal prep.

With 37 grams of protein per serving, this bake keeps you full while delivering the comfort of classic pizza flavors. The addition of spinach and bell peppers adds nutrition without overwhelming the pizza taste everyone loves.

Updated on Sun, 08 Feb 2026 12:25:00 GMT
Golden, bubbling High-Protein Pizza Pasta Bake fresh from the oven, loaded with ground beef, pepperoni, and melty mozzarella. Save
Golden, bubbling High-Protein Pizza Pasta Bake fresh from the oven, loaded with ground beef, pepperoni, and melty mozzarella. | dashofstates.com

My neighbor stopped by one evening smelling something incredible wafting from my kitchen and asked what I was making. When I explained it was pasta bake meets pizza, her eyes lit up. That's when I realized I'd stumbled onto something special: a dish that feels indulgent and comforting but actually fuels you properly. It's become my go-to when I need to feed people well without spending hours at the stove.

I made this for my sister after she mentioned wanting to eat better, and watching her go back for thirds told me everything. She'd been skeptical about the Greek yogurt in the sauce, but once it baked and melted into the pasta, she stopped analyzing and just enjoyed. That moment made me understand that good food doesn't need to announce its health benefits.

Ingredients

  • Lean ground beef (300 g): The backbone of your sauce, it browns quickly and adds richness without overwhelming the other flavors, so don't skip browning it thoroughly.
  • Turkey or regular pepperoni (60 g, sliced): This is your pizza signature, scattered on top where it gets slightly crispy and reminds everyone exactly what they're eating.
  • High-protein pasta (350 g): Choose penne or fusilli so the sauce clings properly, and cooking it just to al dente keeps it from turning mushy during baking.
  • Plain Greek yogurt (250 g): The secret weapon that sounds weird until you taste it, it adds creaminess and protein without the heaviness of traditional béchamel.
  • Part-skim mozzarella (150 g, shredded): Half goes into the sauce for body, half gets scattered on top for that golden, bubbly finish you're after.
  • Grated Parmesan (40 g): A smaller amount adds genuine depth and umami that makes people ask what your secret ingredient is.
  • Large egg: It binds the yogurt sauce and helps it set properly in the oven so it doesn't separate.
  • Small onion, finely chopped: The aromatics matter here, building flavor as they soften and sweeten in the oil.
  • Garlic (2 cloves, minced): Add it after the onion softens so it doesn't burn and turn bitter.
  • Canned crushed tomatoes (400 g): Quality matters because this is your sauce base, and good tomatoes make the whole dish taste fresher.
  • Red bell pepper, diced (optional): It adds sweetness and texture, especially if you're making this for people who appreciate a vegetable.
  • Baby spinach (100 g, optional): Stir it in at the last second so it just wilts and adds nutrition without changing the dish's identity.
  • Dried oregano and basil (1 tsp each): These are non-negotiable for pizza flavor, so don't skip them or substitute fresh at this stage.
  • Chili flakes (½ tsp, optional): A whisper of heat that makes people wonder why it tastes so good without being able to pinpoint why.
  • Olive oil: Just enough to sauté without making everything heavy.

Instructions

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Get your oven ready and prep your vessel:
Preheat to 200°C (400°F) and grease your baking dish generously so nothing sticks to the sides. This step takes a minute but saves frustration later.
Cook the pasta until just shy of tender:
Boil it in salted water until al dente, then drain and set aside. It'll finish cooking in the oven, so don't overdo it now.
Build your flavor base with vegetables:
Drizzle olive oil in a large skillet over medium heat, add your onion and bell pepper if using, and let them soften for 3 to 4 minutes until they're starting to turn golden. You'll smell when they're happy.
Wake up the garlic:
Add minced garlic and cook for just 1 minute, stirring constantly so it softens without browning. The aroma changes completely when it's ready.
Brown your beef properly:
Add the lean ground beef and break it up with a spoon as it cooks, letting it brown on all sides for 5 to 7 minutes. This browning step is where flavor lives, so don't rush it.
Build the tomato sauce:
Stir in crushed tomatoes, oregano, basil, chili flakes if using, and spinach if using. Let everything simmer together for 5 minutes so the flavors merge, then taste and season with salt and pepper.
Create the creamy sauce that makes people ask questions:
In a separate bowl, whisk together Greek yogurt, half of the mozzarella, Parmesan, and egg until completely smooth. Season lightly with salt and pepper, keeping in mind the other elements are already seasoned.
Bring everything together:
In a large bowl, combine the cooked pasta, beef-tomato mixture, and yogurt-cheese sauce, folding gently so the pasta gets coated evenly without breaking.
Transfer and top:
Pour the mixture into your prepared baking dish, spread it evenly, then scatter the remaining mozzarella on top. Arrange pepperoni slices over the cheese in whatever pattern makes you happy.
Bake until golden and bubbling:
Bake for 20 to 25 minutes until the edges are bubbling and the top is golden brown. Let it rest for 5 minutes before serving so the sauce sets and you don't burn your mouth on the first bite.
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Steam rises from a serving of High-Protein Pizza Pasta Bake, revealing a creamy, cheesy texture inside a casserole dish. Save
Steam rises from a serving of High-Protein Pizza Pasta Bake, revealing a creamy, cheesy texture inside a casserole dish. | dashofstates.com

There's a particular satisfaction that comes from pulling this out of the oven: the cheese bubbling at the edges, the pepperoni crispy on top, the whole kitchen smelling like pizza and home cooking. It's the kind of dish that makes people feel cared for without requiring you to spend the whole day cooking.

Why This Works as a Weeknight Dinner

Most high-protein meals feel like obligations you're forcing down, but this one tastes like a treat. The Greek yogurt gives you protein without the grainy texture of lean meat alone, and the melted cheese makes everything feel decadent even though you're not overloading on fat. It's proof that healthy eating doesn't have to taste austere.

Making It Your Own

The beauty of a bake like this is its flexibility without losing its identity. I've added mushrooms when I had them, thrown in olives for extra pizza character, and even swapped ground turkey for beef when that's what I had on hand. The foundation stays solid no matter what you adjust.

Serving and Storage Wisdom

Serve this with a simple green salad to cut through the richness, or if you're feeling celebratory, pour a glass of Chianti alongside. Leftovers actually improve after a day in the fridge as the flavors continue to merge, and you can reheat individual portions in the microwave without drying things out.

  • Store leftovers covered in the fridge for up to 4 days, and it reheats beautifully in a 160°C oven for about 12 minutes.
  • You can assemble this dish up to 8 hours ahead and bake it when you're ready, making it perfect for busy weeknights.
  • Double the recipe easily if you're feeding more people, just add 10 extra minutes to the baking time.
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Family-style High-Protein Pizza Pasta Bake plated with a fresh green salad, ready for a satisfying weeknight dinner. Save
Family-style High-Protein Pizza Pasta Bake plated with a fresh green salad, ready for a satisfying weeknight dinner. | dashofstates.com

This recipe exists because food should nourish your body and your spirit at the same time. It's become the dish I make when I want people to feel good and satisfied, and that matters more than any single ingredient ever could.

Recipe FAQ

Can I make this bake ahead of time?

Yes, assemble the entire dish up to 24 hours in advance and refrigerate. Bake for an additional 5-10 minutes if baking directly from the refrigerator.

What makes the sauce creamy?

Greek yogurt combined with mozzarella, Parmesan, and an egg creates a rich, creamy sauce that holds everything together while baking.

Can I freeze leftovers?

Portion leftovers into airtight containers and freeze for up to 3 months. Thaw overnight in the refrigerator and reheat at 180°C until warmed through.

How do I increase the protein content?

Use high-protein pasta varieties, add extra lean ground beef, or incorporate cottage cheese into the yogurt mixture for additional protein.

What vegetables work well in this bake?

Mushrooms, olives, zucchini, or broccoli florets complement the pizza flavors beautifully. Add them during step 6 with the spinach.

Can I use different meat?

Ground turkey, chicken, or Italian sausage work equally well. For a vegetarian version, use plant-based crumbles or extra vegetables and beans.

High-Protein Pizza Pasta Bake

Hearty pasta bake with pizza flavors, lean beef, pepperoni, and creamy Greek yogurt sauce.

Prep duration
20 min
Cook duration
30 min
Complete duration
50 min
Created by Jordan Miller


Complexity Easy

Heritage American-Italian

Output 6 Portions

Nutritional considerations None specified

Components

Proteins

01 10.5 oz lean ground beef
02 2 oz turkey or regular pepperoni, sliced

Pasta

01 12 oz high-protein pasta such as penne or fusilli

Cheese and Yogurt Sauce

01 1 cup plain Greek yogurt, 0 to 2 percent fat
02 1.5 cups part-skim mozzarella cheese, shredded
03 0.25 cup grated Parmesan cheese
04 1 large egg

Vegetables

01 1 small onion, finely chopped
02 2 cloves garlic, minced
03 14 oz canned crushed tomatoes
04 1 red bell pepper, diced, optional
05 3.5 oz baby spinach, roughly chopped, optional

Spices and Seasonings

01 1 teaspoon dried oregano
02 1 teaspoon dried basil
03 0.5 teaspoon chili flakes, optional
04 Salt and black pepper to taste
05 Olive oil for sautéing

Method

Phase 01

Prepare the Oven and Baking Dish: Preheat oven to 400°F and lightly grease a 9x13-inch baking dish with olive oil or cooking spray.

Phase 02

Cook the Pasta: Bring a large pot of salted water to boil. Add pasta and cook until just al dente according to package directions. Drain and set aside.

Phase 03

Sauté Aromatics and Vegetables: Heat a drizzle of olive oil in a large skillet over medium heat. Add chopped onion and diced bell pepper if using. Sauté for 3 to 4 minutes until softened and fragrant.

Phase 04

Add Garlic: Stir in minced garlic and cook for 1 minute, stirring frequently to prevent scorching.

Phase 05

Brown the Ground Beef: Add lean ground beef to the skillet, breaking it apart with a spoon as it cooks. Continue cooking until browned throughout and cooked through. Drain excess fat if necessary.

Phase 06

Simmer the Meat Sauce: Stir in crushed tomatoes, oregano, basil, chili flakes if using, and spinach if using. Simmer for 5 minutes. Season with salt and black pepper to taste.

Phase 07

Prepare the Yogurt-Cheese Sauce: In a mixing bowl, combine Greek yogurt, half of the shredded mozzarella, grated Parmesan, and egg. Whisk until smooth and well combined. Season lightly with salt and pepper.

Phase 08

Combine All Components: In a large bowl, combine cooked pasta, beef-tomato mixture, and yogurt-cheese sauce. Toss gently until all ingredients are evenly distributed throughout.

Phase 09

Assemble the Casserole: Transfer the combined mixture to the prepared baking dish. Spread evenly, then top with remaining mozzarella cheese. Arrange pepperoni slices in an even layer across the top.

Phase 10

Bake Until Golden: Bake for 20 to 25 minutes until the casserole is bubbling at the edges and the cheese on top is golden brown. Remove from oven and let rest for 5 minutes before serving.

Necessary tools

  • Large pot for boiling pasta
  • Large skillet for browning meat and cooking vegetables
  • Mixing bowls for combining sauce and final assembly
  • 9x13-inch baking dish for casserole preparation and baking
  • Sharp knife and cutting board for vegetable preparation
  • Wooden spoon or silicone spatula for stirring and breaking up meat

Allergy details

Review each component for potential allergens and seek professional medical guidance if you're uncertain.
  • Contains milk from cheese and yogurt
  • Contains eggs
  • Contains wheat from pasta unless gluten-free alternative is used
  • Pre-sliced pepperoni may contain soy or gluten, verify label before use

Nutrient breakdown (each portion)

These figures are approximate and shouldn't replace professional health advice.
  • Energy: 420
  • Fats: 13 g
  • Carbohydrates: 39 g
  • Proteins: 37 g