Baked High-Protein Pepperoni Stromboli

Featured in: All-American Desserts

This hearty stromboli delivers protein-rich satisfaction with a perfect balance of seasoned lean ground beef, spicy pepperoni slices, and melted mozzarella and Parmesan cheeses wrapped in golden pizza dough. The preparation involves sautéing onions and garlic, browning the beef with Italian herbs, then layering everything inside rolled dough before baking to crispy perfection. Serve sliced with warm marinara for a complete Italian-American experience.

Updated on Sun, 08 Feb 2026 12:24:00 GMT
Golden-baked Baked High-Protein Pepperoni Stromboli sliced open on a cutting board, revealing layers of melted mozzarella and savory ground beef. Save
Golden-baked Baked High-Protein Pepperoni Stromboli sliced open on a cutting board, revealing layers of melted mozzarella and savory ground beef. | dashofstates.com

My gym buddy Mike showed up at my kitchen one Tuesday evening, completely skeptical about my claim that I'd finally cracked the protein-packed stromboli. He watched as I pulled a golden, steaming roll from the oven, the cheese bubbling at the edges, and I could see his expression shift from doubt to hunger. That single dinner—shared over marinara sauce and cold beer—became the reason he started asking me to cook instead of hitting the usual takeout spots. Sometimes the best recipes aren't found; they're born from the simple desire to prove something to a friend.

I made this the night my sister announced her engagement, and honestly, it became the unexpected star of the celebration. Everyone was circled around the kitchen island, wine glasses in hand, and when I sliced into that stromboli, the aroma of pepperoni and melted mozzarella cut through all the chatter—suddenly everyone was reaching for a plate. It turned into one of those moments where the food becomes part of the memory itself, not just an afterthought.

Ingredients

  • Pizza dough (1 pound): Store-bought works perfectly here—no shame in skipping the rise time when you're after results, though homemade gives you more control over the texture.
  • Lean ground beef (8 oz): The backbone of your protein hit; don't skimp on the browning step because that's where the flavor develops.
  • Pepperoni slices (2 oz): Those little circles of spice are non-negotiable; they distribute heat throughout every bite.
  • Shredded mozzarella (2 cups): This melts into pools of gooey perfection, so use real cheese, not the pre-shredded kind with the anti-caking powder.
  • Grated Parmesan (1/2 cup): The sharper cousin that cuts through richness and adds a subtle tang.
  • Onions and garlic: Sauté these first until they're fragrant—this is where the foundation of flavor begins, and rushing it shows in the final dish.
  • Italian herbs (1 tsp): Dried works fine here since they'll bloom in the warm beef mixture; fresh herbs would get lost in the baking process.
  • Red pepper flakes (optional, 1/4 tsp): I always add mine because the stromboli is better with a gentle heat that builds as you eat.
  • Egg wash: That single beaten egg transforms the crust from ordinary to glossy and golden-brown.
  • Marinara sauce, for serving: Don't skip this; it's the dipping sauce that turns slices into an event.

Instructions

Product image
Dispense soap hands-free for quick handwashing and easier cleanup while cooking and handling ingredients.
Check price on Amazon
Heat your oven and prep your stage:
Set the oven to 400°F and line a baking sheet with parchment paper so nothing sticks and cleanup is barely a thought.
Build the flavor foundation:
Warm olive oil in a skillet and sauté onions until they turn translucent and soft, about 2–3 minutes, then add garlic for just 30 seconds so it doesn't burn. You'll know it's right when the kitchen smells like an Italian grandmother's approval.
Brown the beef with intention:
Add ground beef to the pan, breaking it apart as it cooks, and don't walk away—stir occasionally until it's fully browned with no pink remaining. Season generously with salt, pepper, Italian herbs, and red pepper flakes, then let it cool for 5 minutes so you don't cook the cheese prematurely.
Roll out your canvas:
On a lightly floured surface, roll the pizza dough into a large rectangle, roughly 12 by 16 inches, keeping the thickness even so it bakes uniformly.
Layer like you mean it:
Spread the cooled beef mixture evenly across the dough, leaving a 1-inch border on all sides to give yourself room to seal. Layer pepperoni over the beef, then scatter both mozzarella and Parmesan across the top in a way that promises every slice gets cheese in every bite.
Roll and seal with confidence:
Starting from a long edge, roll the dough tightly into a log shape, pinching the seam and both ends firmly so nothing unravels during baking. The tighter you roll, the more even the bake and the better the texture.
Get it on the pan and egg-washed:
Place the stromboli seam-side down on your prepared baking sheet, then brush the entire top with beaten egg until it's evenly coated.
Create steam escape routes:
Using a sharp knife, make 3–4 diagonal slits across the top to let steam escape and prevent the crust from becoming soggy.
Bake until golden and cooked through:
Bake for 25–30 minutes until the exterior is deep golden brown and a knife inserted into the center shows fully cooked beef inside. Let it rest for 5 minutes before slicing—this pause lets everything set so your slices stay intact instead of crumbling.
Slice and serve with purpose:
Use a sharp serrated knife to cut into generous portions and serve immediately with warm marinara sauce on the side for dipping.
Product image
Dispense soap hands-free for quick handwashing and easier cleanup while cooking and handling ingredients.
Check price on Amazon
Freshly baked Baked High-Protein Pepperoni Stromboli on a wooden board, served with a small bowl of warm marinara dipping sauce. Save
Freshly baked Baked High-Protein Pepperoni Stromboli on a wooden board, served with a small bowl of warm marinara dipping sauce. | dashofstates.com

There's a specific moment when you pull this stromboli from the oven and the cheese is still bubbling slightly at the edges—that's when you know you've got something special on your hands. That's when it stops being just dinner and becomes the reason people will ask you to cook for them again.

Protein Power Without the Compromise

The magic of this stromboli isn't just that it delivers nearly 40 grams of protein per serving; it's that you genuinely forget you're eating something designed to be good for you. The beef, pepperoni, and dual-cheese situation make it taste decadent, while the lean ground beef keeps it from feeling heavy. I've served this to people who count macros religiously and people who just want good food, and both groups come back for seconds without needing to be convinced.

Customizing Your Filling

Once you've made this version a few times and it becomes second nature, the stromboli becomes a blank canvas for whatever proteins and vegetables you're craving. I've done versions with sautéed mushrooms layered under the beef, roasted red peppers scattered throughout, and even a spinach-and-ricotta variation when I'm feeling lighter. The dough and technique stay the same; only your filling imagination changes.

Pairing and Serving Suggestions

Stromboli demands a simple green salad on the side—something with a tangy vinaigrette to cut through the richness and cleanse your palate between bites. The marinara sauce should be warm when you serve it, and if you've got good bread or garlic bread hanging around, that's never a mistake. A crisp Italian red wine or even a cold beer transforms dinner from casual to intentional.

  • Make a second stromboli and freeze it unbaked for a quick dinner when you're in a pinch.
  • Leftover slices reheat beautifully in a 350°F oven for about 8 minutes until the cheese softens again.
  • Double the filling ingredients if you want to make two strombolis at once—they bake simultaneously with zero extra effort.
Product image
Cook complete meals by frying, sautéing, simmering, and boiling with easy nonstick cleanup every day.
Check price on Amazon
Rustic Baked High-Protein Pepperoni Stromboli topped with golden crust and herbs, resting on parchment paper straight from the oven. Save
Rustic Baked High-Protein Pepperoni Stromboli topped with golden crust and herbs, resting on parchment paper straight from the oven. | dashofstates.com

This stromboli became my answer to the question of how to make real food that happens to be healthy, and I've never looked back. Every time I make it, I'm reminded that the best recipes aren't complicated—they're just intentional.

Recipe FAQ

Can I make this stromboli ahead of time?

Yes, you can assemble the stromboli, wrap it tightly in plastic, and refrigerate for up to 24 hours before baking. Add an extra 5-10 minutes to the baking time if baking cold.

What can I use instead of ground beef?

Turkey, chicken, or Italian sausage work well as alternatives. For a vegetarian version, use plant-based crumbles or sautéed vegetables like mushrooms and bell peppers.

How do I store leftovers?

Store cooled slices in an airtight container in the refrigerator for 3-4 days. Reheat in a 350°F oven for 10 minutes or microwave individual slices for 1-2 minutes.

Can I freeze this stromboli?

Yes, freeze baked and cooled stromboli whole or sliced. Wrap tightly in plastic and foil for up to 3 months. Thaw overnight in the refrigerator before reheating.

Why do I need to cut slits in the top?

The diagonal slits allow steam to escape during baking, preventing the stromboli from bursting open and ensuring even cooking throughout the dough.

What should I serve with stromboli?

Warm marinara sauce is classic for dipping. A simple green salad, roasted vegetables, or Italian soup minestrone make excellent sides to complete the meal.

Baked High-Protein Pepperoni Stromboli

Hearty Italian-American classic with beef, pepperoni and melted mozzarella in golden baked dough.

Prep duration
20 min
Cook duration
30 min
Complete duration
50 min
Created by Jordan Miller


Complexity Medium

Heritage Italian-American

Output 4 Portions

Nutritional considerations None specified

Components

Dough

01 1 pound pizza dough, store-bought or homemade

Meat & Cheese Filling

01 8 ounces lean ground beef
02 2 ounces pepperoni slices
03 2 cups shredded mozzarella cheese
04 1/2 cup grated Parmesan cheese

Vegetables & Seasoning

01 1/2 cup chopped onions
02 2 cloves garlic, minced
03 1 teaspoon dried Italian herbs
04 1/4 teaspoon crushed red pepper flakes, optional
05 Salt and black pepper to taste

Extras

01 1 large egg, beaten for egg wash
02 1 tablespoon olive oil
03 Marinara sauce for serving

Method

Phase 01

Prepare Oven and Baking Surface: Preheat oven to 400°F. Line a baking sheet with parchment paper.

Phase 02

Sauté Aromatics: Heat olive oil in a large skillet over medium heat. Add onions and sauté for 2 to 3 minutes until translucent. Add minced garlic and cook for 30 seconds until fragrant.

Phase 03

Brown Ground Beef: Add ground beef to the skillet, breaking it apart with a spoon as it cooks. Season with salt, pepper, Italian herbs, and red pepper flakes. Cook for 6 to 8 minutes until browned and no longer pink. Remove from heat and cool for 5 minutes.

Phase 04

Shape Pizza Dough: On a lightly floured surface, roll out pizza dough into a large rectangle approximately 12 by 16 inches.

Phase 05

Layer Base Filling: Spread the cooled beef mixture evenly over the dough, leaving a 1-inch border on all sides.

Phase 06

Add Remaining Filling: Layer pepperoni slices over the beef mixture. Sprinkle mozzarella and Parmesan cheeses evenly over the pepperoni.

Phase 07

Roll and Seal Stromboli: Starting from a long edge, tightly roll the dough into a log. Pinch the ends and seam firmly to seal.

Phase 08

Prepare for Baking: Place the stromboli seam-side down on the prepared baking sheet. Brush the entire top surface with beaten egg using a pastry brush.

Phase 09

Score for Steam Release: Using a sharp knife, make 3 to 4 diagonal slits across the top to allow steam to escape during baking.

Phase 10

Bake Until Golden: Bake for 25 to 30 minutes until the top is golden brown and the stromboli is cooked through. Allow to rest for 5 minutes before slicing.

Phase 11

Serve: Slice the stromboli into individual portions and serve immediately with warm marinara sauce.

Necessary tools

  • Large skillet
  • Rolling pin
  • Baking sheet
  • Parchment paper
  • Pastry brush
  • Sharp knife

Allergy details

Review each component for potential allergens and seek professional medical guidance if you're uncertain.
  • Contains wheat and gluten
  • Contains dairy: mozzarella cheese and Parmesan cheese
  • Contains eggs
  • Pepperoni may contain additional allergens; verify product labels for sensitivities

Nutrient breakdown (each portion)

These figures are approximate and shouldn't replace professional health advice.
  • Energy: 520
  • Fats: 25 g
  • Carbohydrates: 35 g
  • Proteins: 37 g