High-Protein Pizza Pasta Bake (Printable)

Hearty pasta bake with pizza flavors, lean beef, pepperoni, and creamy Greek yogurt sauce.

# Components:

→ Proteins

01 - 10.5 oz lean ground beef
02 - 2 oz turkey or regular pepperoni, sliced

→ Pasta

03 - 12 oz high-protein pasta such as penne or fusilli

→ Cheese and Yogurt Sauce

04 - 1 cup plain Greek yogurt, 0 to 2 percent fat
05 - 1.5 cups part-skim mozzarella cheese, shredded
06 - 0.25 cup grated Parmesan cheese
07 - 1 large egg

→ Vegetables

08 - 1 small onion, finely chopped
09 - 2 cloves garlic, minced
10 - 14 oz canned crushed tomatoes
11 - 1 red bell pepper, diced, optional
12 - 3.5 oz baby spinach, roughly chopped, optional

→ Spices and Seasonings

13 - 1 teaspoon dried oregano
14 - 1 teaspoon dried basil
15 - 0.5 teaspoon chili flakes, optional
16 - Salt and black pepper to taste
17 - Olive oil for sautéing

# Method:

01 - Preheat oven to 400°F and lightly grease a 9x13-inch baking dish with olive oil or cooking spray.
02 - Bring a large pot of salted water to boil. Add pasta and cook until just al dente according to package directions. Drain and set aside.
03 - Heat a drizzle of olive oil in a large skillet over medium heat. Add chopped onion and diced bell pepper if using. Sauté for 3 to 4 minutes until softened and fragrant.
04 - Stir in minced garlic and cook for 1 minute, stirring frequently to prevent scorching.
05 - Add lean ground beef to the skillet, breaking it apart with a spoon as it cooks. Continue cooking until browned throughout and cooked through. Drain excess fat if necessary.
06 - Stir in crushed tomatoes, oregano, basil, chili flakes if using, and spinach if using. Simmer for 5 minutes. Season with salt and black pepper to taste.
07 - In a mixing bowl, combine Greek yogurt, half of the shredded mozzarella, grated Parmesan, and egg. Whisk until smooth and well combined. Season lightly with salt and pepper.
08 - In a large bowl, combine cooked pasta, beef-tomato mixture, and yogurt-cheese sauce. Toss gently until all ingredients are evenly distributed throughout.
09 - Transfer the combined mixture to the prepared baking dish. Spread evenly, then top with remaining mozzarella cheese. Arrange pepperoni slices in an even layer across the top.
10 - Bake for 20 to 25 minutes until the casserole is bubbling at the edges and the cheese on top is golden brown. Remove from oven and let rest for 5 minutes before serving.

# Expert Advice:

01 -
  • It delivers serious protein without tasting like a meal-prep container, because the creamy yogurt sauce and melted cheese make it genuinely crave-worthy.
  • You get pizza flavors baked into something that's actually good for you, which means no guilt after seconds.
  • The whole thing comes together in under an hour, making weeknight dinners feel less rushed and more satisfying.
02 -
  • Don't overcook the pasta initially or it'll turn mushy in the oven; al dente is genuinely the target.
  • The yogurt sauce will look thin when you mix it, but the egg and heat transform it into something creamy and stable that holds the whole dish together.
  • If you're making this ahead, let it cool slightly before covering so condensation doesn't pool on top and make everything soggy.
03 -
  • Brown your beef slowly and deliberately; rushing this step means missing out on the deep flavors that make the whole dish sing.
  • Taste your sauce before mixing everything together so you can adjust seasoning once, rather than trying to fix it after baking.
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