Italian Sub Grilled Cheese

Featured in: Midwest Classics

This Italian Sub Grilled Cheese combines classic deli meats with creamy provolone cheese and a zesty lettuce mixture. Butter and grill Italian bread until golden while the cheese melts perfectly. The result is a satisfying, restaurant-quality sandwich ready in just 20 minutes with minimal effort.

Updated on Tue, 20 Jan 2026 14:37:00 GMT
Golden-brown Italian Sub Grilled Cheese sandwich with melted provolone, salami, and pepperoni on buttery bread.  Save
Golden-brown Italian Sub Grilled Cheese sandwich with melted provolone, salami, and pepperoni on buttery bread. | dashofstates.com

One rainy Tuesday I stood at the counter with leftover deli meat and half a loaf going stale, thinking about those corner sub shops where they pile everything high and drizzle vinegar over shredded lettuce. I buttered two slices of bread, layered on salami and provolone, then pressed the whole thing into a hot skillet. The smell alone made me forget I was just using up odds and ends.

I made this for my neighbor after she helped me carry groceries up three flights, and she stood in my doorway eating it over the sink because she couldn't wait. She said it reminded her of the sandwiches her uncle used to bring home wrapped in wax paper, except hotter and less soggy. We both agreed that was a good trade.

Ingredients

  • Italian bread or sturdy white sandwich bread: You need something with backbone here, soft sandwich bread will turn to mush under all that moisture and heat.
  • Unsalted butter, softened: Softened butter spreads evenly without tearing the bread and gives you that golden, crispy crust without burning.
  • Provolone cheese: Melts smooth and mild, letting the meats and vinegar shine without fighting for attention.
  • Salami and pepperoni: These bring the salty, spiced funk that makes it taste like a real Italian deli counter.
  • Shredded iceberg lettuce: Iceberg stays crunchy and doesn't wilt the second it hits warmth, which is exactly what you want here.
  • Mayonnaise: It makes the lettuce topping creamy and helps the vinegar cling instead of pooling at the bottom.
  • Red wine vinegar: Sharp and tangy, this is what wakes everything up and keeps it from feeling heavy.
  • Dried oregano: A little goes a long way, it adds that classic sub shop herby note without needing fresh anything.
  • Pepperoncini rings and red onion (optional): If you like a little heat and bite, these turn a good sandwich into one you think about later.

Instructions

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Mix the lettuce topping:
Toss the shredded lettuce with mayo, vinegar, oregano, salt, and pepper until everything is lightly coated. Let it sit while you build the sandwiches so the flavors can settle in.
Butter the bread:
Spread softened butter on one side of each slice, edge to edge. This is your insurance against a pale, sad crust.
Layer the fillings:
Place two slices buttered side down, then stack on provolone, salami, and pepperoni. Add pepperoncini and onion now if you are using them.
Add the lettuce mixture:
Spoon the dressed lettuce evenly over the meats, pressing it down gently so it stays put. Top with the remaining bread slices, buttered side up.
Grill the sandwiches:
Heat your skillet over medium and set both sandwiches in without crowding them. Press down gently with a spatula and let them cook 3 to 4 minutes per side until the bread turns deep gold and the cheese starts oozing out the edges.
Slice and serve:
Pull them off the heat, cut each sandwich in half, and serve while the cheese is still stretchy. They are best eaten immediately, leaning over a plate.
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Dispense soap hands-free for quick handwashing and easier cleanup while cooking and handling ingredients.
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A close-up of a hot Italian Sub Grilled Cheese cut diagonally, revealing layers of cold cuts and tangy lettuce.  Save
A close-up of a hot Italian Sub Grilled Cheese cut diagonally, revealing layers of cold cuts and tangy lettuce. | dashofstates.com

The first time I served this at a casual dinner, someone asked if I had ordered it from somewhere because it tasted too put together to be homemade. I took that as the highest compliment, even though all I did was turn leftovers into something that felt like a celebration.

What to Serve Alongside

Kettle chips are the obvious move here, salty and crunchy with enough heft to stand up to the sandwich. A simple tomato salad with olive oil and basil keeps things light, or you could go with pickles and olives if you want to lean into the deli vibe. I have also served it with a cup of tomato soup for dipping, which turns it into something almost decadent.

How to Store and Reheat

Honestly, this sandwich does not love the fridge, the lettuce gets limp and the bread goes soft. If you have to save one, wrap it tightly and eat it cold the next day like a regular sub, or reheat it gently in a skillet without adding more butter. It will not be quite the same, but it will still taste good enough to finish.

Ways to Make It Your Own

Swap in mortadella or capicola if you want something a little fancier, or use turkey and ham for a milder version. You can replace the provolone with mozzarella or even a sharp cheddar if that is what you have. Some people like to add a thin smear of pesto or a drizzle of balsamic glaze before closing the sandwich, and I will not stop you.

  • Try sourdough or ciabatta for a chewier, more rustic feel.
  • Add a few banana pepper rings if you want more tang without extra heat.
  • Use garlic butter instead of plain for a little extra punch on the crust.
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Grilled to perfection, this Italian Sub Grilled Cheese features melted cheese, savory meats, and a crisp lettuce topping. Save
Grilled to perfection, this Italian Sub Grilled Cheese features melted cheese, savory meats, and a crisp lettuce topping. | dashofstates.com

This is the kind of sandwich that makes you feel like you know what you are doing in the kitchen, even on days when you absolutely do not. It is fast, forgiving, and always tastes like more than the sum of its parts.

Recipe FAQ

What type of bread works best for this sandwich?

Italian bread or sturdy white sandwich bread are ideal choices. You can also substitute with whole wheat or sourdough bread for different flavors and textures.

How do I prevent the bread from getting too dark while grilling?

Use medium heat and monitor closely during cooking. Press gently with a spatula for even contact with the pan. If browning too quickly, reduce heat slightly and extend cooking time by 1-2 minutes per side.

Can I prepare the lettuce mixture in advance?

Yes, you can combine the lettuce, mayonnaise, vinegar, and seasonings up to 2 hours ahead. Store in an airtight container in the refrigerator and apply to the sandwich just before grilling.

What are some heat options for this sandwich?

For a spicier version, add hot giardiniera, extra pepperoncini rings, or fresh jalapeños. You can also mix a pinch of red pepper flakes into the lettuce mixture for gradual heat.

How should I slice and serve this sandwich?

Allow the sandwich to cool for 1-2 minutes after cooking, then slice diagonally in half for easier handling. Serve immediately while warm with kettle chips or a fresh tomato salad.

Can I use different cured meats?

Absolutely. Substitute with capicola, mortadella, or prosciutto. Adjust quantities based on your preference for salt and richness in the final sandwich.

Italian Sub Grilled Cheese

Melty sandwich featuring Italian salami, pepperoni, provolone, and tangy lettuce grilled until golden and crispy.

Prep duration
10 min
Cook duration
10 min
Complete duration
20 min
Created by Jordan Miller


Complexity Easy

Heritage Italian-American

Output 2 Portions

Nutritional considerations None specified

Components

Bread & Dairy

01 4 slices Italian bread or sturdy white sandwich bread
02 2 tablespoons unsalted butter, softened
03 4 slices provolone cheese

Meats

01 6 slices salami
02 6 slices pepperoni

Lettuce Topping

01 1 cup shredded iceberg lettuce
02 2 tablespoons mayonnaise
03 1 tablespoon red wine vinegar
04 1 teaspoon dried oregano
05 Salt and freshly ground black pepper to taste

Optional Additions

01 2 tablespoons mild pepperoncini rings, drained
02 2 tablespoons thinly sliced red onion

Method

Phase 01

Prepare Lettuce Mixture: In a mixing bowl, combine shredded iceberg lettuce, mayonnaise, red wine vinegar, dried oregano, salt, and black pepper. Mix thoroughly and set aside.

Phase 02

Butter the Bread: Lay out all four bread slices and spread one side of each with softened unsalted butter.

Phase 03

Assemble Sandwich Base: Place two buttered bread slices on a work surface with buttered side down. Top each slice with 2 slices provolone cheese, 3 slices salami, and 3 slices pepperoni.

Phase 04

Add Optional Toppings: If desired, distribute pepperoncini rings and thinly sliced red onion evenly over the meats and cheese on each sandwich.

Phase 05

Layer Lettuce Mixture: Spread the prepared lettuce mixture evenly over the meats and cheese on each sandwich base.

Phase 06

Complete Sandwiches: Top each sandwich with the remaining bread slices, buttered side up, to enclose the filling.

Phase 07

Grill Sandwiches: Heat a large skillet or grill pan over medium heat. Place assembled sandwiches in the pan and cook 3 to 4 minutes per side, applying gentle pressure with a spatula, until bread achieves golden color and cheese is completely melted.

Phase 08

Finish and Serve: Remove sandwiches from heat, slice diagonally in half, and serve immediately while hot.

Necessary tools

  • Skillet or grill pan
  • Spatula
  • Mixing bowl
  • Knife and cutting board

Allergy details

Review each component for potential allergens and seek professional medical guidance if you're uncertain.
  • Contains wheat from bread
  • Contains milk from cheese, butter, and mayonnaise
  • Contains eggs from mayonnaise; verify specific brand labels
  • Contains pork from salami and pepperoni
  • Check all labels for potential trace allergens

Nutrient breakdown (each portion)

These figures are approximate and shouldn't replace professional health advice.
  • Energy: 540
  • Fats: 34 g
  • Carbohydrates: 35 g
  • Proteins: 24 g